#icushort 212: How to calculate dose of FFP to be transfused #esbicm #shorts

Summary

Key Points

• —Medical staff often order four units of FFP for patients with deranged coagulation profiles, such as increased INR or prothrombin time. 0:02
• —Ordering four units of FFP would replace approximately 1 liter of plasma. 0:06
• —The video questions whether a fixed four-unit dose is always necessary or if a specific formula should be used to calculate the required FFP dose. 0:12
• —It is generally assumed that replacing 25-30% of coagulation factors can achieve hemostasis in patients not on heparin or other anticoagulants. 0:23
• —A normal patient's total plasma volume is approximately 40 ml per kg of body weight. 0:26
• —For a 70 kg patient, the total plasma volume is around 3 liters, with roughly 1 liter being plasma. 0:28
• —One unit of FFP typically contains 200 to 250 ml of plasma. 0:36
• —A more precise method to calculate the required FFP dose is 10 to 15 ml per kg of body weight. 0:47
• —This calculation suggests that the number of FFP units needed can vary, potentially being less than four (e.g., three) or more (e.g., six) depending on the patient's specific requirements. 0:51